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Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Recruiting
18 years and older
All
Phase 4
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Overview

The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.

Eligibility

Inclusion Criteria:

• All adult patients (>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.

Exclusion Criteria:

  • High clinical suspicion for Legionella pneumonia
  • Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
  • Antibiotics not for CAP
  • Pregnant women (based on clinical assessment as part of standard of care)
  • Severe CAP as defined by the ATS/IDSA criteria
  • Corrected QT prolongation (> 440 ms in men and > 460 ms in women)
  • Receiving a different antibiotic (e.g quinolones)
  • Admission > 24 hours
  • Known to be a prisoner

Study details
    Community-acquired Pneumonia

NCT07164131

Mayo Clinic

15 October 2025

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