Overview
Investigating the Relationship Between Oral Microbiome Alterations and Tumor Markers in Locally Advanced Oral Squamous Cell Carcinoma (LA-OSCC) After Neoadjuvant Chemoimmunotherapy: Implications for Therapeutic Efficacy, Chemoresistance, and Prognostic Assessment
Eligibility
Inclusion Criteria:
- Oral squamous cell carcinoma (OSCC) diagnosed as locally advanced (T3N0M0, T1-3N1M0, T4aN0-2M0, T1-4aN3M0, or T4bN0-3M0) according to AJCC staging criteria.
- Their age ranged from 18 to 80 years;regardless of gender.
- Absence of prior head and neck radiation therapy or chemotherapy.
- Adequate blood function: white blood cell count (WBC) >＝3.5×10^9/L, platelet count (PLT) >＝75×10^9/L：Hemoglobin concentration (HGB) >＝90g/L.
- Adequate liver function： total bilirubin (TBIL) <＝ the upper limit of normal, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <＝2.5 times the upper limit of normal.
- Adequate renal function：urinary white blood cells < 10, red blood cells < 10, cast count < 5 per high-power field, serum creatinine in the range of 186-351 mmol /L, and creatinine (CRE) <＝ the upper limit of normal.
- The heart, brain, lung and other vital organs function and general condition can tolerate NACI.
- PS score <＝2.
- Signed informed consent form and voluntarily agreeing to participate in this study.
Exclusion Criteria:
- Pregnancy or lactation (for female participants).
- Patients with a history of epilepsy or psychiatric disorders that were not well-controlled.
- Patients with severe allergic diathesis or suspected or confirmed alcohol or drug addiction.
- Patients who had taken antibiotics within 7 days before enrollment.