Overview
Use of sorption technologies in patients undergoing maintenance hemodialysis with inflammatory syndrome and clinical manifestations of uremia
Description
This study will involve 30 hemodialysis patients selected based on examination results showing elevated C-reactive protein (CRP) and/or interleukin-6 (IL-6) levels. Participants will undergo hemoadsorption with the Jafron HA130 cartridge performed concurrently with hemodialysis: three times per week during the first month, twice per week during the second month, and once per week during the third month.
The following parameters will be assessed: inflammatory markers (CRP, IL-1, IL-6, IL-8, β2-microglobulin, free light chains of immunoglobulins), parathyroid hormone (PTH), standard biochemical blood tests (creatinine, urea, calcium, phosphorus, albumin, iron metabolism), and complete blood count. Analyses will be performed at baseline (before inclusion) and monthly thereafter.
Eligibility
Inclusion Criteria:
- Adequate dialysis defined by a KT/V index ≥ 1.4
- No active inflammatory process or infection
- Age ≥ 18 years
- Receiving standard hemodialysis regimen three times weekly, at least 4 hours per session
- Participants with elevated interleukin-6 (IL-6) and/or C-reactive protein (CRP) levels exceeding local laboratory reference values
Exclusion Criteria:
- Current use of steroids or immunosuppressive therapy
- History of kidney transplantation
- Diagnosis of cancer
- Pregnancy