Overview
The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg) intravenous methadone.
Eligibility
Inclusion Criteria:
- English-speaking
- Age over 18 years old
- Scheduled cesarean delivery
Exclusion Criteria:
- Any contraindication to the administration of a spinal technique for anesthesia
- History of intolerance or adverse reaction to opioid medications
- History of chronic pain, opioid use >30 OME/day, or substance use disorder
- History of obstructive sleep apnea, chronic obstructive pulmonary disease, or respiratory compromise (SpO2 <92% on room air, or has a pre-existing oxygen requirement)
- History of liver or kidney failure
- Diagnosis of pre-eclampsia with current pregnancy
- Depression requiring more than one medication
- Planned use of CSE technique
- BMI >50.0 kg/m2
- ASA status IV, V
- No prior history of an ECG demonstrating QTc > 440ms
- Surgical complication requiring conversion to general anesthesia