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Clinical Prediction Model for In-Hospital Rebleeding in Acute Non-Variceal Upper Gastrointestinal Bleeding

Clinical Prediction Model for In-Hospital Rebleeding in Acute Non-Variceal Upper Gastrointestinal Bleeding

Recruiting
18 years and older
All
Phase N/A

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Overview

ANVUGIB is a serious condition that can cause symptoms like vomiting blood or passing black stools. Although treatments have improved, about 10% to 30% of patients experience rebleeding shortly after their initial treatment, which increases the risk of death.

Currently, doctors use tools like the Glasgow-Blatchford Score, Rockall Score, and AIM65 Score to predict how patients with ANVUGIB might recover. However, these tools are not very effective at identifying patients who are at risk for rebleeding. This study aims to create a new, more accurate prediction model to help doctors identify high-risk patients earlier. The investigators believe that a new predictive model, which combines patient symptoms, lab test results, and imaging findings, will improve the ability to identify patients at high risk of rebleeding compared to existing tools.The goal is to provide doctors with a more reliable tool to guide their decisions, such as when to give preventive treatments or increase monitoring. This could lead to better outcomes and reduce the risk of complications or death.

This study uses patient data collected during routine care to develop and test the new model, ensuring the findings are directly applicable to real-world clinical settings.

Eligibility

Inclusion Criteria:

  • age exceeding 18 years,
  • Clinical diagnosis of Acute Non-Variceal Upper Gastrointestinal Bleeding ,
  • patients who underwent endoscopy within 24 hours of admission with confirmation of non-variceal bleeding

Exclusion Criteria:

  • Upper Gastrointestinal Bleeding during hospitalization;
  • transfer from other hospitals;
  • variceal bleeding;
  • lower gastrointestinal bleeding.;
  • bleeding attributed to systemic diseases like disseminated intravascular coagulation (DIC) and hematological disorders;
  • patients with incomplete clinical data or laboratory test results;
  • patients who either requested early discharge or declined gastroscopy.

Study details
    Acute Non-variceal Upper Gastrointestinal Bleeding

NCT06697691

Junwei Yan

14 October 2025

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