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Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section

Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section

Recruiting
19 years and older
Female
Phase 4
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Overview

The investigators aim to compare the analgesic efficacy of intravenous acetaminophen alone versus combination of acetaminophen/ibuprofen (Maxigesic®IV) in multimodal analgesia after cesarean section.

Eligibility

Inclusion Criteria:

  • Patients scheduled for elective cesarean section
  • Gestational age > 37+0 weeks

Exclusion Criteria:

  • Emergency cesarean section
  • Multiple pregnancy (e.g. twins, triplets)
  • Body weight < 50 kg
  • Preeclampsia
  • History of hypersensitivity to acetaminophen or ibuprofen
  • History of upper gastrointestinal tract bleeding or gastric ulcer
  • Underlying liver disease
  • Underlying kidney disease or GFR < 90 mL/min/1.73m2
  • Heart failure or severe hypertension
  • History of asthma
  • Chronic use of barbital or tricyclic antidepressants

Study details
    Cesarean Section
    Postoperative Pain

NCT06479122

Seoul National University Hospital

12 September 2025

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