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Consistency of LGE-MRI Fibrosis and EAM Low-voltage Area

Consistency of LGE-MRI Fibrosis and EAM Low-voltage Area

Recruiting
18 years and older
All
Phase N/A

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Overview

This study aims to:

  1. Assess the consistency of LGE-MRI bi-atrial fibrosis and electroanatomical mapping of bi-atrial low voltage region
  2. To evaluate the electroanatomical characteristics of different types of fibrosis (dense fibrosis, patchy fibrosis, etc.) in different locations of the left and right atrium;
  3. To explore the correlation between preoperative and postoperative bi-atrial fibrosis and long-term recurrence in patients with atrial fibrillation.

Eligibility

Inclusion Criteria:

  1. Adult patients (≥18 years old) who are willing to participate in this study and can sign informed consent;
  2. Atrial fibrillation was diagnosed and catheter ablation was proposed

Exclusion Criteria:

  1. Left atrial thrombus or left atrial appendage thrombus;
  2. Severe chronic obstructive pulmonary disease (FEV1/ FVC<70%, FEV1<50% predicted value);
  3. Absolute contraindications of anticoagulation therapy;
  4. Currently pregnant;
  5. Contraindications for LGE-MRI (claustrophobia, pacemaker implantation, eGFR<30ml/min for renal insufficiency, severe obesity, pregnancy, gadolinium chelating agent allergy, etc.);
  6. refuse to participate in the study;
  7. other physical or mental incapacity to participate in the study.

Study details
    Atrial Fibrillation

NCT06552845

China National Center for Cardiovascular Diseases

12 September 2025

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