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CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

Recruiting
18-90 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care. Assess the efficacy (PROMIS Pain Intensity and Hernia-Related QOL) of a CYP2D6-guided opioid prescribing approach for patients undergoing elective VHRs.

Eligibility

Inclusion Criteria:

  • > 18 years age undergoing a ventral hernia repair (VHR) ≥1.5 cm in diameter with mesh.

Exclusion Criteria:

  • ventral hernia <1.5 cm
  • primary ventral hernia repair (VHR) without a mesh
  • emergency operative procedure
  • receiving chronic opioid therapy (defined as use of opioids on most days for >3 months)
  • allergy to opioids
  • women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup

Study details
    Ventral Hernia

NCT06565546

University of Florida

12 September 2025

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