Overview
Sleep deprivation is a prevalent problem in modern societies. Sleep deprivation can cause hormonal changes, such as an increase in cortisol, as well as inflammation. Animal studies have shown an increase in inflammatory cytokine production following sleep deprivation. Additionally, humans experiencing sleep deprivation may experience a decrease in natural killer cells and lymphocytes.
Physicians, particularly those in surgical specialties, are often subjected to sleep deprivation as part of their medical residency training. This study hypothesizes that after 24-hour shifts, there is an increase in inflammatory response and impairment of the immune response against unspecific activation. This proposal aims to provide insight into the impact of sleep deprivation on the immune system of surgery residents by characterizing the phenotype and function of immune cells, as well as their correlation with biometric data.
Eligibility
Inclusion Criteria:
- Healthy subjects
- Surgery residents in a 24-hour shift rotation
- Gender of subjects: Males and females
- Age of subjects: 18 years old and older
- Racial and Ethnic Origin: Any race or ethnicity
Exclusion Criteria:
- Unwilling/unable to sign informed consent
- Vulnerable Subjects/Subject Capacity to provide consent