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Concurrent Nab-paclitaxel with Intensity-modulated Radiation Therapy in Patients with Stage III-IVa Nasopharyngeal Carcinoma

Concurrent Nab-paclitaxel with Intensity-modulated Radiation Therapy in Patients with Stage III-IVa Nasopharyngeal Carcinoma

Recruiting
18-70 years
All
Phase 1
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Overview

The goal of this clinical trial is to determine the maximum tolerated dose and the recommended phase II dose for nab-paclitaxel when administered concurrently with radiotherapy in nasopharyngeal carcinoma. Researchers will observe the toxicity response of patients receiving nab-paclitaxel at 180 mg/m², 200 mg/m², 230 mg/m², and 260 mg/m².

Eligibility

Inclusion Criteria:

  • Pathologically confirmed nasopharyngeal carcinoma
  • III-IVa (AJCC8th)
  • age 18-70
  • PS score 0-1
  • normal functions to tolerate chemotherapy and radiotherapy

Exclusion Criteria:

  • The presence of other malignant neoplasms within the preceding five years, with the exception of carcinoma in situ, adequately treated non-melanoma skin cancer and papillary thyroid cancer, is permitted.
  • Symptomatic heart failure, unstable angina, myocardial infarction, active infections requiring systemic therapy, psychiatric disorders, or family and social factors

Study details
    Nasopharyngeal Carcinoma (NPC)

NCT06611150

Sun Yat-sen University

9 September 2025

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