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Analysis of Protein Expression in Serum of KOA Subjects

Analysis of Protein Expression in Serum of KOA Subjects

Recruiting
50 years and older
All
Phase N/A

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Overview

In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.

Eligibility

Inclusion Criteria:

  • Adults over 50 years old without knee pain

Exclusion Criteria:

  1. Clinical diagnosis of knee osteoarthritis
  2. Taking anti-inflammatory and analgesic drugs in the past month
  3. Taking blood-lipid-lowering drugs or health foods in the past month
  4. Received any acupuncture treatment in the past 3 weeks

Study details
    Knee Osteoarthritis

NCT06553313

China Medical University Hospital

14 October 2025

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