Overview
The goal of this observational study is to learn about the amide proton transfer-weighted imaging for rectal cancer response assessment after neoadjuvant therapy. The main question it aims to answer is:
• Does amide proton transfer-weighted imaging predict the cancer response before surgery? Participants will underwent amide proton transfer-weighted imaging as part of their regular MRI examination.
Eligibility
Inclusion Criteria:
- Locally advanced rectal cancer(cT3-4, or cN+), resectable, histologically confirmed rectal adenocarcinoma
- Received neoadjuvant therapy before surgery
- Complete radical resection of rectal cancer and postoperative pathological examination
- Informed consent and signed the informed consent form
Exclusion Criteria:
- Poor image quality, such as severe artifacts
- Complicated with intestinal obstruction, intestinal perforation and other cases requiring surgical treatment
- The interval between preoperative MRI and surgery was more than 2 weeks
- Prior treatment for rectal cancer
- History of other malignant tumors
- Patients who cannot undergo MRI examination due to contraindications or relative contraindications
- Patients were lost to follow-up or voluntarily withdrew from the study due to adverse reactions or other reasons