Overview
The aim of this study was to apply PET/MR techniques targeting TSPO to explore the temporal and spatial alterations characterizing neuroinflammation in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis of MSA disease.
Eligibility
Inclusion Criteria:
- Age> 35 years old, gender is not limited;
- Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria;
- all patients had been ruled out of polyQ disease by genetic testing;
- Voluntarily participate in this study and sign the informed consent form.
Exclusion Criteria:
- pregnancy or breastfeeding;
- contraindications to MRI examination or inability to cooperate in completing neuroimaging examination;
- previous history of other neurological disorders or presence of other organic intracranial lesions on neuroimaging that cannot be interpreted by MSA, such as epilepsy, trauma, tumors, or high-grade cerebral white matter degeneration (Fazekas grade 2 and above);
- History of alcohol or drug abuse