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Changes in Eye Shape With Myopia Management Interventions

Changes in Eye Shape With Myopia Management Interventions

Recruiting
21-30 years
All
Phase 4

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Overview

The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses. The main questions it aims to answer are:

  • do low-dose atropine and soft multifocal contact lenses affect the shape of the peripheral eye?
  • are changes in peripheral eye shape from these interventions influenced by changes in the focusing system of the eye?

Participants will:

  • have multiple different types of photos taken
  • have their prescription for glasses/contacts checked
  • have their eye health checked, including the use of dilating eye drops
  • be randomly assigned to use eye drops every night or wear special contact lenses daily instead of their typical contacts
  • will complete five study visits over the course of 12 months

Researchers will compare young adults using low-dose atropine to those wearing soft multifocal contact lenses and to those using no intervention to see if using these interventions affects retinal shape.

Eligibility

Inclusion Criteria:

  • best corrected visual acuity of 20/25 or better in each eye
  • nearsighted
  • current contact lens wearer
  • normal binocular vision (to be determined by an examiner at the first study visit)

Exclusion Criteria:

  • eye diseases (including lazy eye or eye turn)
  • pregnant, nursing, or planning a pregnancy in the next 12 months
  • history of refractive surgery (e.g., LASIK)
  • history of myopia control treatment
  • sensitivity to anesthetics or preservative in eye drops
  • difficulty with pupillary dilation

Study details
    Myopia

NCT06450132

Ohio State University

8 September 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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