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Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial

Urethral PeRfusion Index-Guided Hemodynamic ManagemenT in Patients Having Major Abdominal Surgery: the UPRIGHT Randomized Feasibility Trial

Recruiting
45 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

We will perform this single-center pilot trial to determine if the intraoperative urethral perfusion index is higher in patients assigned to maintaining postinduction baseline urethral perfusion index than in patients assigned to routine care (with blinded urethral perfusion index monitoring). As pre-planned substudies, we will also assess the agreement between a) urethral perfusion index-derived pulse rate and heart rate measured with an electrocardiogram and b) between the urethral perfusion index and the peripheral perfusion index.

Eligibility

Inclusion Criteria:

  • at least 45 years old
  • scheduled for elective major abdominal surgery (involving visceral organs with an expected duration of at least 120 minutes)
  • indication for an arterial catheter
  • indication for an urinary catheter

Exclusion Criteria:

  • Pregnancy
  • Planned surgery: nephrectomy, liver or kidney transplantation surgery
  • Patients who previously had surgery on the urethra or bladder
  • Patients without clinical indication for continuous blood pressure monitoring with an intraarterial catheter

Study details
    Urethral Perfusion Index
    Tissue Perfusion
    Microcirculation

NCT06799832

Universitätsklinikum Hamburg-Eppendorf

14 October 2025

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