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A Phase 2 Study of MZE829 in Adults with APOL1 Kidney Disease

A Phase 2 Study of MZE829 in Adults with APOL1 Kidney Disease

Recruiting
18-65 years
All
Phase 2
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Overview

This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease

Description

An open-label Phase 2 study is designed to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype.

Eligibility

Key Inclusion Criteria:

  • APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2
  • Chronic kidney disease with persistent albuminuria

Key Exclusion Criteria:

  • Organ or bone marrow transplantation
  • History of cancer within past 2 years, excepted for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer
  • Conditions that may alter drug absorption, e.g., history of bariatric surgery
  • Type I diabetes
  • Pregnant or currently nursing

Other inclusion/exclusion criteria defined in protocol apply.

Study details
    Proteinuric Kidney Disease

NCT06830629

Maze Therapeutics

6 September 2025

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