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The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

Recruiting
6-99 years
All
Phase N/A

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Overview

This study plans to learn more about whether a stakeholder-informed, standardized inpatient vaccination program will increase influenza vaccination rates of hospitalized children across US pediatric health systems. The first part of the study is to form a multidisciplinary team of stakeholders, including parents, providers, nurses, pharmacists, informaticists, data analysts and communication experts across three sites in synthesizing a best practice implementation guide for an inpatient influenza vaccination program, which will then be piloted at these three sites.

Description

The overarching goal of this proposal is to determine whether a stakeholder-informed, standardized inpatient influenza vaccination program will increase influenza vaccination rates of hospitalized children across diverse U.S. pediatric health systems. Building upon preliminary data and experience with pediatric inpatient influenza vaccine delivery, the investigators will engage a multidisciplinary team of stakeholders in synthesizing a best practice implementation guide for an inpatient influenza vaccination program across three sites. The next phase of the study, using a novel adaptive trial design, will be to implement and test the program across 12 health systems. Finally, the investigators will evaluate the program's impact using an established dissemination and implementation framework.

Eligibility

Inclusion Criteria:

  • At least 6 months of age
  • Admitted to an inpatient unit at a participating health system
    Exclusion
  • Admission to critical care sites or hematology-oncology services

Exclusion Criteria:

  • At least 6 months of age
  • Admitted to an inpatient unit at a participating health system
    Exclusion
  • Admission to critical care sites or hematology-oncology services

Study details
    Influenza

NCT05832307

University of Colorado, Denver

5 September 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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