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Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Recruiting
18 years and older
All
Phase N/A
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Overview

This study is being done to find out if patient blood samples can be used to perform individualized modeling of cancer therapy-related side effects.

Description

PRIMARY OBJECTIVES:

I. Generate induced pluripotent stem cells (iPSC's) from patients receiving cancer treatment.

II. Differentiate patient iPSC's into cardiomyocytes and/or neurons or other cell types that may be relevant to modeling cancer therapy-related adverse effects, such as cardiotoxicity and neurotoxicity.

III. Use patient specific iPSC-derived cells to:

IIIa. Model cancer therapy-related toxicities; IIIb. Better understand the mechanisms of toxicities; IIIc. Determine if patient specific genetic variants are causative of toxicities; IIId. Screen novel protective therapies for cancer therapy-related toxicities.

OUTLINE: This is an observational study.

Patients undergo blood sample collection and have their medical records reviewed on study.

Eligibility

Inclusion Criteria:

  • * Any patient >= 18 years of age
    • Planned or receiving any potentially toxic cancer therapy including but not limited to chemotherapy, targeted and immunotherapies

Exclusion Criteria:

  • Inability on the part of the patient to understand the informed consent or be compliant with the protocol

Study details
    Hematopoietic and Lymphatic System Neoplasm
    Malignant Solid Neoplasm

NCT06640010

Mayo Clinic

4 September 2025

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