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Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients

Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients

Recruiting
18-54 years
Female
Phase N/A
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Overview

Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.

Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum.

The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.

Eligibility

Inclusion Criteria:

  • Poor response according to "Bologna criteria"

Exclusion Criteria:

  • Allergy to metoclopramide
  • Prolactinemia
  • Women treated with dopamine agonists

Study details
    Poor Responders in IVF

NCT03560583

Barzilai Medical Center

3 September 2025

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