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Statin Combined with Amlodipine Treats Primary Aldosteronism

Statin Combined with Amlodipine Treats Primary Aldosteronism

Recruiting
18-70 years
All
Phase 4
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Overview

The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1: Statin combined with amlodipine besylate, scheme 2: Statin combined with Spironolactone and Amlodipine besylate. scheme 3: Amlodipine besylate combined with Spironolactone , to observe the changes in plasma aldosterone level, 24-hour urinary aldosterone, blood pressure, and long-term cardiovascular risk.

Eligibility

Inclusion Criteria:

  • Clinical diagnosis of primary aldosteronism

Exclusion Criteria:

  • Allergy to drugs in this study
  • Pregnancy
  • Severe liver and kidney dysfunction
  • Mental illness

Study details
    Primary Aldosteronism
    Statin
    Mineralocorticoid Receptor Antagonist
    Hypertension

NCT06523465

Third Military Medical University

2 September 2025

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