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Process-based Therapy for Difficult-to-treat Anxiety Disorders and Depression

Process-based Therapy for Difficult-to-treat Anxiety Disorders and Depression

Recruiting
18-65 years
All
Phase N/A

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Overview

The aim of this study is to test the relative efficacy of Process-based Therapy compared to traditional CBT delivered in routine practice (r-CBT) for difficult-to-treat anxiety disorders and depression.

Description

Process-based Therapy (PBT) is a new framework to intervention planning, based on the use of ecological momentary assessment (EMA) data, feedback of dynamic network analysis and matching of interventions to central nodes of the network. Although preliminary support for its applicability has been reported from a single-case study, there are no data on the feasibility and effectiveness in a larger clinical sample. The investigators have translated a Training Manual of PBT and modified for delivery of CBT in Mental Health Service. The aim of this study is to test the relative efficacy of PBT compared to traditional CBT delivered in routine practice (r-CBT) for difficult-to-treat anxiety disorders and depression.

Eligibility

Inclusion Criteria:

  • A primary DSM-5 diagnosis of depressive or anxiety disorder
  • At least two unsuccessful attempts of pharmacological or psychological treatment according to the German guidelines for the treatment of depression or anxiety disorders (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF)
  • Age 18-65 years
  • Sufficient knowledge of the German language
  • Participating patients are not required to discontinue medication, but to keep medication constant over the treatment period

Exclusion Criteria:

  • Increased suicidality
  • Substance abuse or dependency
  • Borderline personality disorder
  • Pervasive developmental disorder
  • Psychotic disorder
  • Eating disorder
  • Bipolar disorder
  • Severe physical illness

Study details
    Depression
    Anxiety Disorder

NCT06517589

Goethe University

14 October 2025

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