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Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10

Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10

Recruiting
12-36 years
All
Phase N/A

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Overview

To date, there are no methods for assessing the risk of oral developmental defects that could predict long-term adverse effects in childhood cancer survivors. Having such a method at our disposal would enable us to better assess the risk to develop those defects and will help us provide new prevention and treatment strategies to ensure a healthy oral development.

The aims of this study are :

  • Assess the caries risk in childhood cancer survivors compared with a control group.
  • Assess the dental development defects risk in childhood cancer survivors compared with a control group.

Description

This will be an international study comparing the Childhood Cancer Survivors (CCS) and a control group.

A questionnaire will be provided to the patients to gather information. A standard of care dental examination will then take place in a dental office in the Cliniques Universitaires Saint-Luc. We also collect medical data to complete the files.

Eligibility

Inclusion Criteria:

  • age below 10 at cancer diagnosis (for the CCS group).
  • Chemotherapy must have been used to treat the patient (For the CCS group).
  • The patient is 12 years old or older at the time of the follow-up appointment of the present study

Exclusion Criteria:

  • A patient who was diagnosed and treated after 10 years old.
  • Patient below 12 years old at time of study recruitment
  • Patients with syndrome or diseases that involve teeth impairment*
  • Pregnant patient
  • Refusal or inaptitude to undergo dental and radiographic examination

Study details
    Chemotherapy Effect
    Dental Caries
    Malocclusion
    Childhood Cancer
    Tooth Defect

NCT06517927

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

1 September 2025

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