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40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations

40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations

Recruiting
50-85 years
All
Phase N/A
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Overview

This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's disease. Specifically, it examines the effects of 40 Hz tACS applied to frontal brain regions versus fronto-temporal regions on gamma oscillations and working memory in healthy elderly individuals.

Eligibility

Inclusion Criteria:

  • healthy elderly between 50-80 years of age
  • normal or corrected to normal eye vision
  • right-handed
  • non-smokers
  • at least 70 % accuracy in working memory training task

Exclusion Criteria:

  • history of neurological or psychiatric disorders including seizures or epilepsy,
  • Taking CNS, blood pressure and other medications
  • having metal implants in the head and neck
  • significant cognitive decline meassured by The Montreal Cognitive Assessment (MoCA)

Study details
    Alzheimer Disease
    Cognitive Decline

NCT06740864

The National Brain Mapping Laboratory (NBML)

14 October 2025

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