Overview
The purpose of this study is to evaluate the diagnostic performance of circulating microRNAs in detecting the presence of germ cell cancer in patients with small testicular mass or retroperitoneal post-chemotherapy residual mass and suitable for testis sparing surgery and retroperitoneal lymph node dissection, respectively.
Eligibility
COHORT A:
Inclusion Criteria:
- Age >= 18 years
- Single testicular lesion, with < 2 cm diameter and < 30 % testicular volume involvement;
- Negative Serum Tumour Markers;
- Suitable for testis sparing surgery;
- Informed consent.
Exclusion Criteria:
- None
COHORT B:
Inclusion Criteria:
- Age >= 18 years
- Single/multiple post-chemotherapy retroperitoneal lymph node lesion, with > 1 cm (non seminomatous) / > 3 cm (seminomatous) diameter in patients with previous testicular germ cell primary tumour;
- Negative Serum Tumour Markers;
- Suitable for retroperitoneal lymph node dissection;
- Informed consent.
Exclusion Criteria:
- None