Overview
To evaluate the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing urethral stricture recurrence after direct visual internal urethrotomy.
Description
The most common aetiology of urethral strictures is idiopathic, followed by iatrogenic causes, including transurethral resection, urethral catheterization, prostate cancer treatments, and previous hypospadias surgery.
The recurrence rates are higher with previously treated, long and multiple strictures, penile compared with bulbar strictures, and those with perioperative infection.
It has been reported that post-transurethral resection of the prostate (TURP) to receive or not receive a COX-2 inhibitor (rofecoxib 25 mg/day) for 20 days. At 1 year of follow-up, a urethral stricture had been diagnosed in 17 and 0 % of cases without and with COX-2 treatment, respectively
Eligibility
Inclusion Criteria:
- Age ≥ 18 years
- American Society of Anesthesiologists (ASA) score ≤3.
- Urethral stricture length ≤ 1.5 cm
Exclusion Criteria:
- Recurrent urethral stricture ≥ 2 times.
- Pelvic fracture urethral distraction defect (PFUDD).