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Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

Recruiting
20 years and older
All
Phase N/A
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Overview

The aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Description

The main clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Past studies investigated the effect of manual therapy of exercise for individuals with hemophilia and found to enhance muscle strength, balance, fitness and promote quality of life. However, less study has evaluated the safety and effectiveness of manual therapy combined with exercise for individuals with multiple hemophilic arthropathy. Therefore, the aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Eligibility

Inclusion Criteria:

  • over 20 years old and diagnosed with severe hemophilia
  • those who receive prophylaxis regularly
  • there are more than 2 target joints (hemophilic arthropathy)

Exclusion Criteria:

  • unwilling to sign the informed consent
  • any neurological disease or specific musculoskeletal condition (such as fracture) one year ago
  • more than 3 (excluding 3) joint replacement surgeries (different joints)
  • unable to walk due to hemophilia joint disease or any other diseases
  • major bleeding events that pose risks or hinder research
  • unable to follow instructions due to cognitive impairment

Study details
    Severe Hemophilia

NCT06535971

Far Eastern Memorial Hospital

30 August 2025

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