Overview

The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are:

• Can human lung stem cell proliferate in vitro.
• Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment.

Eligibility

Inclusion Criteria:

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1. Age under 55, regardless of gender

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2. Patients with COPD lung disease who are going to undergo bronchoscopic biopsy

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3. No genetic diseases and other respiratory diseases

Exclusion Criteria:

• Other conditions determined by the investigators to be unsuitable for inclusion, such as difficult sampling, difficult follow-up, and complicated with other serious diseases