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Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With Mucositis

Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With Mucositis

Recruiting
18-75 years
All
Phase N/A
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Overview

The goal of this study is to calculate pharmacokinetic parameters and to evaluate the trough levels of posaconazole reached in patients with different stages of mucositis, due to chemotherapy and total body irradiation.

Eligibility

Inclusion Criteria:

  • Patients receiving allogeneic stem cell transplantation - Treated with prophylactic posaconazole: oral suspension (200mg three times daily) or tablet (300mg once daily) to prevent invasive fungal infections

Exclusion Criteria:

  • Gastroparesis
  • Vomiting or diarrhea within 2 hours after intake of posaconazole
  • Concomitant administration of potent inducers of the enzyme UGT1A4: carbamazepine,phenytoin, phenobarbital, rifabutin, rifampicin,...
  • Age under 18 years

Study details
    Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

NCT01420562

Universitaire Ziekenhuizen KU Leuven

14 October 2025

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