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SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx

SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx

Recruiting
18-70 years
All
Phase 2
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Overview

This trial aims to evaluate the safety and efficiency of SBRT followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx

Eligibility

Inclusion Criteria:

  • Laryngeal (T3-4N0-3M0 ) and hypopharyngeal ( T2-4N0-3M0) cancers staged by AJCC8th
  • age 18-70
  • PS score 0-1
  • normal functions to tolerate chemotherapy, immunotherapy and radiotherapy

Exclusion Criteria:

  • Patients with a combination of other malignant tumours
  • Individuals with contraindications to immunotherapy

Study details
    Laryngeal Cancer
    Hypopharynx Cancer

NCT06611137

Sun Yat-sen University

26 August 2025

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