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Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium

Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium

Recruiting
18 years and older
All
Phase N/A
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Overview

The investigators want to study the effect of environmental nitrogen enrichment on the allergy burden in pollen-sensitized subjects.

Description

The investigators want to study allergen-specific IgE reactivity from a cross-sectional sample of pollen-allergic patients (and negative controls) against environmental and experimental pollen samples. Following aspects will be compared:

  • To study the basophil degranulation with different amounts of pollen on fresh patient-derived basophils, to determine the concentration of pollen needed to degranulate 5% (EC5), and 50% (EC50) of basophils.
  • To study he overall intensity (quantitative), as well as IgE-mediated hyper- or hyporecognition of different fragments in the pollen samples (qualitative) in a subset of patients.
  • To associate allergic rhinoconjunctivitis and food-pollen syndrome related symptoms with reactivity to different pollen samples.

Eligibility

Inclusion Criteria:

  • Positive skin prick test for grass and/or birch pollen

Exclusion Criteria:

  • Desensitization therapy during the last two years

Study details
    Pollen Allergy

NCT06714149

prof. dr. Rik Schrijvers

14 October 2025

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