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Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial

Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial

Recruiting
18-70 years
Female
Phase N/A
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Overview

  • Efficacy of olanzapine on weight gain in advanced stage gynecologic cancer
    • Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Description

-Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Eligibility

Inclusion Criteria:

  • Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy
  • ECOG 0-1
  • Normal CBC,Liver, renal function
  • Communication in Thai language or Thai caregiver
  • Inform consent

Exclusion Criteria:

  • Pregnancy
  • Active infection
  • Bowel obstruction or history of bowel surgery
  • On dopamine receptor antagonists or psychiatric or anticonvulsant medication
  • Olanzapine allery
  • Abnormal function of liver and renal
  • Diabetic melitus or morbid obesity
  • patient can't selfcare

Study details
    Weight Gain

NCT06288854

Department of Medical Services Ministry of Public Health of Thailand

14 October 2025

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