Overview
experimental study with analysis on tissues. This study aims to study cardiometabolic risk from a genetic, clinical, instrumental and laboratory point of view in a population of subjects with obesity.
Description
Compared to normal clinical practice, if you decide to participate in the study you will be asked to:
- allow the collection of an additional study-specific amount of blood as part of a blood sample already provided for by clinical practice during the dietetic visit; The sample will be used to perform the genetic and laboratory analyses required by the study.
- Undergo an additional study-specific visit within one month of the dietetic visit. will be subjected to the measurement of the degree of vascular aging and the evaluation of the health of his/her arteries, through non-invasive examinations.
Eligibility
Inclusion Criteria:
- • Age > 18 years
- BMI > 30 Kg/m2
- In primary prevention for cardiovascular disease
- Ability to communicate, make themselves understood and adhere to study-specific procedures
- Willingness to participate in the study and obtain informed consent
Exclusion Criteria:
- Patients already enrolled by the Research Units involved in the enrolment
- Glycated hemoglobin level > 55 mmol/L
- Patients suffering from obesity secondary to endocrinological diseases or iatrogenic causes
- Patients with heterozygous Familial Hypercholesterolemia (Dutch Lipid Score - DLS>8)
- Patients suffering from hypercholesterolemia secondary to lipid or iatrogenic extra-metabolic pathologies
- Patients suffering from systemic inflammatory or oncological diseases
- Patients on active treatment with GLP-1 analogues
- Pregnancy and breastfeeding
- Any medical or surgical condition that makes the patient's adherence to the study protocol complex or inconsistent.