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Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Recruiting
18-80 years
All
Phase N/A
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Overview

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

Eligibility

Inclusion Criteria:

  • Age 18-80 years
  • Listed for liver transplantation at MGH
  • Calculated MELD-Na score <= 25
  • Able to consent

Exclusion Criteria:

  • Status 1a
  • Cardiac or pulmonary disease
  • Prior liver transplant
  • Requiring pressors at the time of liver offer
  • MELD<15 and asymptomatic from liver disease

Study details
    Liver Transplant

NCT06088758

Massachusetts General Hospital

21 August 2025

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