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Blood Biomarkers for Screening of Alzheimer's Disease

Blood Biomarkers for Screening of Alzheimer's Disease

Recruiting
50 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

The goal of this observational study is to estimate the screen performance of blood biomarkers of interest (Aβ40 and Aβ42, P-Tau181, P-Tau217, GFAP and NfL) in patients with Alzheimer's disease (AD), mild cognitive impairment due to AD, and cognitively normal individuals. The main questions it aims to answer are:

  • to identify core blood biomarker suitable for early screening of AD.
  • to establish a comprehensive model for the early identification of AD.

Eligibility

Inclusion Criteria:

  • Age ≥ 50 years;
  • AD (meets the 2011 NIA-AA AD diagnostic criteria), or MCI (meets the 2004 Peterson MCI diagnostic criteria), or cognitively normal subjects;
  • Signed informed consent form.

Exclusion Criteria:

  • The presence of other disorders that can cause cognitive impairment;
  • Unable to cooperate with the completion of cognitive assessment;
  • Refusal to draw blood.

Study details
    Alzheimer's Disease
    Blood Biomarkers

NCT06477484

Peking University First Hospital

21 August 2025

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FAQs

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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