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GRACE - Graduated Response for Advanced COPD With Enhanced Support

GRACE - Graduated Response for Advanced COPD With Enhanced Support

Recruiting
65 years and older
All
Phase N/A

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Overview

The aim of this study is to explore the feasibility and potential for a positive impact of a graduated response for advanced COPD with Enhanced Support. The study is a randomized controlled trial of:

  • systematic needs assessment
  • advance care planning
  • crossectoral virtual conferences. Researchers will compare quality of life and healthcare use of the intervention group with a control group that will be assessed for intervention need at the last follow-up.

Description

The current study is a non-blinded randomized controlled pilot trial. The control group will be offered treatment as usual whereas the intervention group will be allocated to the GRACE model of care. In total, 100 patients and their caregivers will be included. The patients are all community dwelling and attached to the Outpatient Respiratory Medicine Clinic at Hvidovre Hospital. The patients will be randomized by block randomization to intervention and control group with a ratio of 1:1. Furthermore, the patients will be stratified according to which municipality they belong to, to ensure we gather feasibility data from two municipalities. The control group will be offered to be assessed for their eligibility for palliative care through the existing visitation conference at the end of the trial period. Endpoints include: Patient-reported (quality of life, anxiety and depression, self-efficacy), caregiver-reported ( caregiver burden, anxiety and depression, well-being) and patient healthcare use.

Eligibility

Inclusion Criteria:

  • COPD
  • Exacerbation within the last year
  • Living in Høje Taastrup or Copenhagen
  • Cognitively relevant
  • Clinical Frailty scale 6+
  • ICECAP-SCM at least two scores of:
    1. 1, 2
    2. 1, 2
    3. 1, 2
    4. 1, 2
    5. 1, 2, 3
    6. 1, 2
    7. 1, 2

Exclusion Criteria:

  • Dementia
  • Psychosis
  • Substance abuse
  • Hearing or speech impairment
  • Cancer
  • Receiving specialized palliative care or other similar interventions
  • Immediately dying

Study details
    COPD (Chronic Obstructive Pulmonary Disease)

NCT06967324

Copenhagen University Hospital, Hvidovre

16 August 2025

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