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Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy

Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy

Recruiting
18-90 years
All
Phase N/A

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Overview

Chronic postoperative pain (CPP) is typically defined as pain persisting for 3 months or more after surgery[1]. CPP is a common and increasingly prevalent morbidity, leading to long-term psychological issues, reduced quality of life, and impaired functionality[2]. To reduce the incidence of CPP, high-risk patients are identified, and various surgical techniques, pharmacological agents, and regional anesthesia techniques are employed[3].

The primary aim of our study is to scale chronic pain at 1 hour, 3 months, and 1 year post-nephrectomy using the Numeric Rating Scale (NRS), ranging from 0 to 10. The secondary aim is to evaluate the effects of factors influencing chronic postoperative pain on the NRS scores.

Description

Patients gender, age, height(m), weight(kg), body mass index(kg/m2), diagnosis, smoking and alcohol history, comorbidities, surgical technique and duration, complications, lymph node dissection, thrombectomy, adrenalectomy, amount of bleeding(cc), need for blood transfusion, need for intensive care, analgesia technique used, amount of opioids and non-opioid analgesics used perioperatively, amount of vasopressors used, heart rate(bpm) and mean arterial pressure(mmHg) at induction, post-intubation, post-extubation, and 1 hour postoperatively, presence of postoperative pain, chronic analgesic use history(more than 3 uses per week), presence of fibromyalgia, frequent urinary tract infections, diagnosed with central sensitization disorders, bruxism, depression-panic attacks, allergic asthma, irritable bowel syndrome, and migraines will be recorded. The effects of these factors on NRS scores at 1 hour, 3 months, and 1 year postoperatively will be examined.

Eligibility

Inclusion Criteria: -Patients aged 18-90 years,

  • ASA I-IV,
  • undergoing elective nephrectomy under general anesthesia will be included in the study.

Exclusion Criteria:

  • Patients who cannot be reached by phone and hose who die within the 1-year postoperative period will be excluded from the study.

Study details
    General Anesthesia
    Chronic Pain
    Postoperative
    Acute Pain
    Postoperative
    Surgery
    Anesthesia
    Chronic Pain
    Analgesic Drugs
    Epidural Analgesia
    Nephrectomy

NCT06673979

Istanbul University - Cerrahpasa

15 August 2025

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