Overview
The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.
Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration
Description
Patients will be randomly divided into two groups: one receiving intravenous low-dose epinephrine and tranexamic acid, while the other will receive TXA alone as the control. Randomization to be done using a computer-generated table.
The study will be done a superiority clinical trial. with an estimated 24 hour blood loss of 300 ml, with standard deviation of 150 ml. a power of 80% and alpha 5%, an estimated sample size of 80 is needed to detect a difference.
Eligibility
Inclusion Criteria:
- Patients undergoing knee joint arthroplasty.
- Saudi and Non-Saudi Patient.
- Patients who have Complete medical record.
Exclusion Criteria:
- End stage renal disease
- Liver cirrhosis
- Coagulopathy
- Pre-operative Hgb <10 5.
- History of cerebrovascular accident or myocardial infarction in past 12 months.
- History of Heart failure.
- History of arrhythmia.
- History of pheochromocytoma, thyrotoxicosis and glaucoma.
- Pregnancy or breast feeding
- History of Deep venous thrombosis or pulmonary embolism
- Allergy to epinephrine or tranexamic acid