Overview
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Eligibility
Inclusion Criteria
- Healthy adults aged 18-35 years
- Absence of any significant medical or psychiatric disease (as per the investigators' judgment)
- Nonsmoker
- Nonpregnant
- History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping)
- Hypertension status information available for both biological parents
- Ability to understand study procedures and to comply with them for the entire length of the study
- Ability to understand English and provide informed consent
Exclusion Criteria
- Age <18 or >35 years
- Body mass index <18.5 or ≥30 kg/m2
- Pregnant or lactating
- Unable to determine history of HTN in participant's biological parents or subject being adopted
- Use of tobacco, vaping, marijuana products or other drugs
- Excessive caffeine consumption (>400 mg/day)
- Excessive alcohol consumption (>7 drinks/week for women, >14 drinks/week for men)
- Office SBP/DBP ≥130/80 mmHg
- Daytime ambulatory SBP/DBP ≥130/80 mmHg
- Fasting glucose ≥126 mg/dl
- Glomerular filtration rate <60 mL/min/BSA
- History of significant medical or psychiatric disorders (as per the investigators' judgment)
- Regular use of prescription medications other than contraceptives
- Use of melatonin supplements or any other over-the-counter sleep aid
- Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale >10)
- Moderate-to-severe insomnia (Insomnia Severity Index >14)
- Restless leg syndrome (as per the Cambridge-Hopkins questionnaire)
- Excessive daytime sleepiness (Epworth Sleepiness Scale >15)
- Extreme chronotype (Morningness-Eveningness Questionnaire >69 or <31)
- Night shift work
- Ongoing participation in other research studies (as per the investigators' judgment)
- Any other medical, geographic, or social factor making study participation impractical
- Not English-speaking and/or inability to provide informed consent
- Exclusionary for blood draws: hemoglobin <11.6 g/dL in women / <13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.