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Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure

Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure

Recruiting
40-70 years
All
Phase 2/3
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Overview

Dexmedetomidine is a potent alpha-2 adrenergic receptor agonist. In addition, dexmedetomidine-induced stimulation of the postsynaptic alpha-2 adrenergic receptor on the cerebral blood vessels can cause cerebral vasoconstriction and decrease cerebral blood flow

Eligibility

Inclusion Criteria:

ASA I-II Patients scheduled for elective robot-assisted laparoscopic prostatectomy

Exclusion Criteria:

  • • ASA physical status > II
    • Cardiac patients
    • Cerebrovascular disease
    • Glaucoma
    • Hepatic failure
    • Renal failure
    • History of anaphylactic reaction to dexmedetomidine or mannitol
    • Hemodynamic instability
    • Cannot measure ONSD for example due to ophthalmological problems.
    • Any cause of preoperative increase in ICP for example intracranial space occupying lesions.

Study details
    Dexmedetomidine

NCT07064720

Cairo University

22 July 2025

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