Overview
Dexmedetomidine is a potent alpha-2 adrenergic receptor agonist. In addition, dexmedetomidine-induced stimulation of the postsynaptic alpha-2 adrenergic receptor on the cerebral blood vessels can cause cerebral vasoconstriction and decrease cerebral blood flow
Eligibility
Inclusion Criteria:
ASA I-II Patients scheduled for elective robot-assisted laparoscopic prostatectomy
Exclusion Criteria:
- • ASA physical status > II
- Cardiac patients
- Cerebrovascular disease
- Glaucoma
- Hepatic failure
- Renal failure
- History of anaphylactic reaction to dexmedetomidine or mannitol
- Hemodynamic instability
- Cannot measure ONSD for example due to ophthalmological problems.
- Any cause of preoperative increase in ICP for example intracranial space occupying lesions.