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Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches

Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches

Recruiting
18 years and older
All
Phase N/A

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Overview

The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to:

  1. show that intravenous lidocaine infusion causes a clinically significant reduction in pain scores in patients with moderate/severe headache pain following non-traumatic subarachnoid hemorrhage;
  2. show that intravenous lidocaine infusion is safe in treating headache following non-traumatic subarachnoid hemorrhage;
  3. and report vasospasm prevalence in the cohort.

Participants will receive lidocaine infusion as treatment for non-traumatic subarachnoid hemorrhage headache and provide pain scores (on a numeric pain scale) every two hours the patients are awake for a maximum of seven days. Monitoring for vasospasm will occur as part of the patients regular medical care.

Eligibility

Inclusion Criteria:

  • Patients > 18 years;
  • Have a favorable neurological status defined as Hunt and Hess score ≤ 3 (as it accounts for patient awareness);
  • Can communicate numeric pain scores;
  • Are diagnosed with non-traumatic subarachnoid hemorrhage

Exclusion Criteria:

  • The patient is diagnosed with traumatic subarachnoid hemorrhage;
  • If the patient is < 18 years of age;
  • If numeric pain scores could not be captured for > 3 days of hospitalization;
  • If the patient had a prior aneurysm;
  • Chronic pain not associated with non-traumatic subarachnoid hemorrhage diagnosis;
  • A disability before the stroke (> 2 on modified Rankin Scale score);
  • A Hunt and Hess score > 3;
  • Contraindications to lidocaine (significant cardiac disease, arrhythmia, seizures, previous allergic reaction to lidocaine

Study details
    Subarachnoid; Hemorrhage
    Nontraumatic
    Headache

NCT06582810

University of Kansas Medical Center

28 July 2025

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