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Effetivity of Dutasteride and Aloe Vera Extract Combination on Angiogenesis and Obstruction on Benign Prostatic Hyperplasia

Effetivity of Dutasteride and Aloe Vera Extract Combination on Angiogenesis and Obstruction on Benign Prostatic Hyperplasia

Recruiting
50 years and older
Male
Phase 1
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Overview

This study is a double blinded RCT with pre-post test design on the effect of combination of dutasteride and aloe vera, compared to dutasteride only, on uroflowmetry results, prostate volume, and VEGF serum level among patients with benign prostate hyperplasia. The treatment was given for 12 weeks

Eligibility

Inclusion Criteria:

  • Diagnosed with BPH clinically or radiologically (prostate volume > 30 gram, Qmax <15 mL/s)
  • Willing to participate to the study

Exclusion Criteria:

  • Clinically or radiologically suspected of having prostatic cancer
  • Previous prostatic surgery
  • Patients with urinary retention
  • Patients with BPH complications: urinary tract infections, urolithiasis, or hydroneprhosis
  • Previously consumed alpha blocker or 5ARI in the last 6 months
  • Have consumed aloe vera extract routinely

Study details
    BPH (Benign Prostatic Hyperplasia)

NCT07065682

Universitas Diponegoro

21 July 2025

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