Overview
Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Eligibility
Inclusion Criteria:
- Aged ≥18 years
- Stable clinical condition for >3 weeks (e.g., no exacerbations)
- Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
- Informed consent documented by signature
Exclusion Criteria:
- Severe daytime resting hypoxemia (SpO₂ <88%)
- Long-term oxygen therapy
- Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
- Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
- Women who are pregnant or breastfeeding
- Enrolment in another clinical trial involving active treatment