Overview
Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials.
To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.
Description
Sensitivity Analyses Excluding high risk of bias studies
Excluding short follow-up (<1 year)
Eligibility
Inclusion Criteria:
- Adults ≥18 years with diagnosed hypertension
Blood pressure controlled at target values defined by the study (e.g., <140/90 mmHg or <130/80 mmHg)
Any comorbidity allowed unless the study focuses on pregnancy or pediatric population
Exclusion Criteria:
- Observational or retrospective studies
Pediatric or pregnant participants
Case reports, editorials, or conference abstracts without full data
Studies not reporting mortality outcomes separately for controlled BP