Overview
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
Description
. oPRP Treatment & Second IVF Cycle (Study Cycle)
- Following the first IVF cycle, patients will undergo their first oPRP injection:
- Timing: 1-2 weeks after the onset of the next menstrual cycle.
- Procedure: Under IV sedation, a patient's autologous PRP will be prepared and injected directly into both ovaries under transvaginal ultrasound guidance.
- Second IVF Cycle (oPRP Study Cycle)
- The same ovarian stimulation protocol will be used for consistency.
- A second oPRP injection will be performed on stimulation days 2-5 to enhance folliculogenesis.
- Ovulation will be triggered at the same follicular size thresholds, and oocyte retrieval will follow identical protocols.
- Fertilization methodology will be identical to the first cycle unless no fertilization is identified in the first cycle.
- Embryo Development Analysis: Up to 15 embryos will be cultured in the AI incubator, where time-lapse imaging will track their morphokinetics, and AI-based analysis will assess embryo viability and implantation potential.
Eligibility
Inclusion Criteria:
- No none contraindications to IVF or PRP treatment
- Adequate ovarian reserves and AMH level
- Willingness to undergo two IVF cycles and oPRP treatment
Exclusion Criteria:
- Anovulation due to menopause or perimenopause
- Any health conditions that are contraindicated for IVF or oPRP treatment