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MEASUREMENT OF CIRCULATING MUTATION BURDEN

MEASUREMENT OF CIRCULATING MUTATION BURDEN

Recruiting
30-50 years
Female
Phase N/A
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  • Simplified (AI rewritten)

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Overview

Cancer-free women with a hereditary predisposition to breast and/or ovarian cancer

Description

This proof-of-concept trial will be conducted with family members being monitored for a predisposition to breast and/or ovarian cancer linked to a BRCA1/2 gene mutation.

The study will be proposed to two sisters from the same sibling:

  • one is a carrier of the genetic mutation
  • and the other not,

Blood tests will evaluate the Mutation Burden cfMB

Eligibility

Inclusion Criteria:

  • Female participant
  • Participant undergoing oncogenetic follow-up at the Centre François Baclesse
  • Participant belonging to a pair of related biological siblings
  • Within the sibling pair, one participant is a carrier of a hereditary predisposition linked to a BRCA1/2 mutation (case), and the other participant is not a carrier (control).
  • Participant between 30 and 50 years of age
  • Participant affiliated to a social security scheme
  • Participant having given her consent to participate by signing an informed consent form prior to any specific study-related procedure.

Exclusion Criteria:

-

Study details
    Breast Carcinoma
    Genetic Predisposition to Cancer
    BRCA Mutation
    cfMB
    Mutation Burden

NCT06792721

Centre Francois Baclesse

14 July 2025

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