Overview
The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session. The main questions it aims to answer are:
Is there a change in oxidative stress markers measured from saliva after root canal treatment? Is there a difference between the change of oxidative stress markers in patients using different root canal sealers after root canal treatment?
Researchers will compare bioceramic-based and epoxy resin-based root canal sealers to see if there are significant differences in oxidative stress markers measured from patients' saliva after root canal treatment.
- Participants will be informed about all procedures before starting the clinical process.
- Participants are expected to allow saliva sampling two times: first sample will be collected on root canal treatment session and second sample will be collected on the 30th day after root canal treatment.
- Participants will be informed in writing about the treatment procedure before starting the clinical process.
- Participants are expected to sign the informed consent form on a voluntary basis.
Eligibility
Inclusion Criteria:
- Systemically healthy, ASA1 patients,
- Phase 1 periodontal treatment was performed,
- Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth,
- The lesion measured <2 cm on radiographic evaluation,
- The vitality of the tooth was checked by EPT (Ai-Pex, Woodpecker, China) and Cold test (Cerkamed, Poland) and confirmed to be devitalised,
- Socioculturally able to participate in the treatment,
- Individuals who did not smoke or drink alcohol
Exclusion Criteria:
- Patients who have used antibiotics in the last three months and analgesics in the last two weeks
- Patients who smoke and/or abuse alcohol
- Patients younger than 18 years or older than 45 years,
- Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6)
- Pregnant or lactating women,
- Patients with poor oral hygiene,
- Patients who had head and neck radiotherapy,
- With obesity,
- Active periodontal disease,
- Periodontal pocket depth over 3mm,
- There is enough loss of material in the relevant tooth to prevent adequate isolation or to require post placement,
- Clinical examination of the relevant tooth showing symptoms in percussion-palpation,
- Radiographically, the lesion is seen in relation to anatomical formations such as the mandibular canal and maxillary sinus,
- Patients who required prophylactic antibiotic use before invasive dental procedures were excluded from the study.
- Patients who did not attend the follow-up appointment and patients who experienced complications during expansion (instrument seperation, perforation, etc.) were excluded from the study.