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Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial

Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial

Recruiting
20-65 years
All
Phase N/A
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Overview

Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial

Description

doxapram will be administered intravenously (IV) during spontaneous breathing trial. diaphragmatic excursion will be evaluated by an expert in respiratory muscle ultrasound

Eligibility

Inclusion Criteria:

  • Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial

Exclusion Criteria:

  • Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm

Study details
    COPD
    Mechanical Ventilation
    Weaning From Mechanical Ventilation

NCT07022704

Cairo University

8 July 2025

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