Overview
This randomized, double-blind, controlled clinical trial aims to compare the effects of low-flow sevoflurane and desflurane anesthesia on physiological parameters and recovery profiles in adult patients undergoing ENT surgeries. The primary outcomes include heart rate, mean arterial pressure, peripheral oxygen saturation, end-tidal CO₂, and arterial blood gas values. Secondary outcomes involve time to spontaneous respiration, extubation, and response to verbal commands.
Description
This prospective study investigates the clinical effects of low-flow anesthesia using two commonly utilized volatile agents, sevoflurane and desflurane, in adult patients undergoing elective ENT surgeries, specifically rhinoplasty, mastoidectomy, and tympanoplasty. A total of 40 ASA I-II patients, aged 18-65, will be randomly assigned into two groups: Group S (sevoflurane) and Group D (desflurane).
All participants will undergo general anesthesia with endotracheal intubation. After 2 minutes of preoxygenation with 100% oxygen at 10 L/min, anesthesia will be induced and maintained with the assigned volatile agent under low-flow settings (1 L/min, 50% O₂-50% air). Hemodynamic and respiratory parameters (HR, MAP, SpO₂, EtCO₂) will be recorded at predefined time points, along with arterial blood gas analysis (pH, pCO₂, pO₂, COHb).
Recovery times including return of spontaneous respiration, extubation, and verbal response will be documented. This study aims to provide clinical evidence on the optimal anesthetic choice under low-flow conditions, supporting safer, more efficient, and environmentally conscious anesthesia practices.
Eligibility
Inclusion Criteria:
- Adults aged between 18 and 65 years
- Classified as ASA physical status I or II
- Scheduled to undergo elective ENT surgery (rhinoplasty, mastoidectomy, or tympanoplasty)
- Requiring general anesthesia with endotracheal intubation
- Providing written informed consent
Exclusion Criteria:
- ASA physical status III or higher
- History of malignant hyperthermia or delayed emergence from anesthesia
- Morbid obesity (BMI ≥ 35)
- Coronary artery disease, congestive heart failure, COPD, liver or kidney disease
- Pregnancy or breastfeeding
- Allergy to halogenated anesthetics
- Respiratory pathology
- Substance or alcohol abuse