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Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease

Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease

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18 years and older
All
Phase N/A
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Overview

This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.

Description

The investigators prospectively measured plasma NT-proBNP levels in consecutive patients referred to the center for elective diagnostic coronary angiography due to symptoms or signs of coronary artery disease over a two- year period. Patients with conditions known to elevate NT-proBNP levels, including heart failure, severe valvular disease, atrial fibrillation, severe chronic kidney disease (eGFR < 30 mL/min), prior coronary artery bypass grafting, or age over 80 years, were excluded.

Eligibility

Inclusion Criteria:

  • patient referred for elective coronary angiography due to suspected CAD.
  • NT-proBNP measurement during hospitalization

Exclusion Criteria:

  • heart failure
  • severe valvular disease
  • atrial fibrillation
  • severe chronic kidney disease (eGFR < 30 mL/min)
  • prior coronary artery bypass grafting
  • age over 80 years

Study details
    Chronic Coronary Syndrome
    Chronic Coronary Total Occlusion
    Coronary Arterial Disease (CAD)
    Stable Chronic Angina
    NT-pro-BNP

NCT07013344

IRCCS Ospedale San Raffaele

18 June 2025

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